Impact Factor 3.644 ... Frontiers in Endocrinology Cancer Endocrinology Toggle navigation Section (current) Section; ... Cuthbertson DJ and Pritchard DM (2020) Frequency and Causes of False-Positive Elevated Plasma Concentrations of Fasting Gut Hormones in a Specialist Neuroendocrine Tumor Center. Euthyroid and primarily hypothyroid patients develop milder and significantly more asymmetrical Graves ophthalmopathy. Ahmadi H, Shams PN, Davies NP, Joshi N, Kelly MH. doi: 10.1111/cen.14296, 4. With an Impact Factor of 3.675, Frontiers in Endocrinology is the 2nd most cited open-access journal in Endocrinology & Metabolism. Kendler DL, Lippa J, Rootman J. Current evidence suggests that patient presenting with asymmetric or unilateral GO may progress to bilateral disease, which clinicians treating patients with GO need to be aware of. There is a need for better documentation of the suggestions that asymmetric/unilateral GO might run a milder course or be a prelude to bilateral disease. Immunity (2020) 52:275–94.e279. Front. However, the exact mechanisms causing asymmetry remain elusive. Eur J Endocrinol (2006) 154:511–7. doi: 10.1007/s40618-020-01258-w, 13. If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. Journal Impact 2018 di Frontiers in Endocrinology è 3.630 (Ultimi dati nel 2019). Clearly, there is a need for a consensus in the definitions of asymmetric and unilateral disease. BMC Ophthalmol (2013) 13:21. doi: 10.1186/1471-2415-13-21, 12. N Engl J Med (2011) 364:1920–31. With an Impact Factor of 3.519 Frontiers in Endocrinology is the 4th most-cited open-access Endocrinology & Metabolism journal and ranks in top impact metrics FRONTIERS HOME ABOUT Moreover, previous studies have shown no difference in regards to race (13) and sex (29), but more recent data, including our recent multicenter study (12) and a cohort of 354 Chinese patients (36), have shown that male sex is associated with asymmetry. Read More . However, in a recently published retrospective hospital-based report from India, unilateral disease was much higher at 36% and significantly more common among silent presenters compared to the clinically active group (33). Clin Endocrinol (2020). Wiersinga WM, Smit T, van der Gaag R, Mourits M, Koornneef L. Clinical presentation of Graves’ ophthalmopathy. Clin Endocrinol (2017) 86:247–55. Many risks factors have been associated with asymmetry. doi: 10.4103/0301-4738.83612, 21. Bilateral versus unilateral thyroid eye disease. Eur J Endocrinol (2008) 158:69–75. Diagnosing unilateral or asymmetric GO without any other signs of GO and especially in the absence of hyperthyroidism or high TRAb titer suggestive of Graves’ disease can be challenging (41) and requires increased clinical awareness and usually imaging of the orbits. Cardiomyopathy is the leading cause of increased mortality in diabetes. Frontiers in Neuroendocrinology Impact Factor, IF, number of article, detailed information and journal factor. Clinicians involved in the care of patients with GO need to be able to identify unilateral or asymmetric GO, as timely recognition of asymmetry may expedite referral to specialist services and facilitate further management. Endocrinol. Given that the pathophysiological mechanisms causing unilateral or asymmetric GO appear to be similar to the well-described bilateral GO, treatment of asymmetric GO is generally the same with bilateral disease and is usually dependent on disease severity. New insights into the pathogenesis and nonsurgical management of Graves orbitopathy. A 48-year-old woman was admitted to our hospital because of moon face and edema. However, since asymmetric disease may progress to bilateral GO thereby increasing patients’ anxiety and deteriorating their mental health status and quality of life as alluded to above, it is important that patients are managed promptly. Unilateral proptosis in thyroid eye disease with subsequent contralateral involvement: retrospective follow-up study. Endocrinol. View all Endocrinology Impact Factor, IF, number of article, detailed information and journal factor. Nat Rev Endocrinol (2020) 16:104–16. Read the latest articles of Frontiers in Neuroendocrinology at ScienceDirect.com, Elsevier’s leading platform of peer-reviewed scholarly literature Angle Orthodontist (1981) 51:214–26. doi: 10.1056/NEJMoa1012985, 44. Efficacy and safety of mycophenolate mofetil in patients with active moderate-to-severe Graves’ orbitopathy. doi: 10.1043/0003-3219(1978)048<0141:AAOAIT>2.0.CO;2, 16. The disease most often presents bilaterally and symmetrically with lid retraction, exophthalmos. Impact Factor 3.644 | CiteScore 3.4More on impact ›, Mechanisms and Novel Therapies in Graves’ Orbitopathy: Current Update Smoking cessation advice and restoring the euthyroid state are important pillars in the management of asymmetric GO. doi: 10.1111/j.1365-2265.1993.tb00516.x, 39. Endocrinol., 17 December 2020 doi: 10.1016/j.bjps.2006.07.001, 20. In another study, male subjects exhibited asymmetric disease (proptosis and overall asymmetry) three-fold more frequently compared with women, while women with hyperthyroidism demonstrated more symmetry compared with euthyroid and hypothyroid individuals of either sexes (23). doi: 10.1097/01.iop.0000235499.34867.85, 29. Multi-center study on the characteristics and treatment strategies of patients with Graves’ orbitopathy: the first European Group on Graves’ Orbitopathy experience. doi: 10.1530/EJE-11-0548, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. While most patients with GO present with bilateral disease, asymmetric or unilateral GO may affect a significant proportion of patients diagnosed with GO. In severe cases GO can be sight-threatening, thus requiring a prompt referral to specialist services (7) upon diagnosis. Citations (Scopus total) Articles published (total) ... Frontiers in Endocrinology. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. doi: 10.1530/EJE-18-0039. Endocr Pract (2001) 7:110–2. Der Journal Impact 2019 von Frontiers in Endocrinology beträgt 3.630 (neueste Daten im Jahr 2020). Such studies may provide further answers in regards to GO development and management. Verma SK, Jain N, Saraf S, Singh SK. Shah SM, Joshi MR. An assessment of asymmetry in the normal craniofacial complex. doi: 10.1097/OPX.0b013e3181890dc7, 22. In our recently published study, asymmetry was defined as bilateral disease with one or more of the following features: difference between the two eyes in exophthalmos by ≥2 mm; difference in palpebral aperture by ≥2 mm; difference in eyelid swelling by ≥1 grades; difference in eyelid erythema by ≥1 grades; difference in conjunctival redness by ≥1 grades; presence of dysthyroid optic neuropathy in one eye only. The editor and reviewers' affiliations are the latest provided on their Loop research profiles and may not reflect their situation at the time of review. Loop is the open research network that increases the discoverability and impact of researchers and their work. Radiological criteria for asymmetry, such a right-to-left ratio of more than 1.4 in extraocular muscle diameter, as obtained by CT measurements based on normative data, have also been proposed (24). Age-related changes in the normal sagittal relationship between globe and orbit. Naik MN, Vasanthapuram VH. Impact Factor 3.644 ... Diabetes is a specialty section of Frontiers in Endocrinology and Frontiers in Public Health. 2010-2020: Scope: Frontiers in Endocrinology publishes rigorously peer-reviewed research from basic molecular and cellular communication to clinical care, advancing our understanding of the endocrine system, and leading to novel therapies for some of the most prevalent health issues such as obesity, diabetes, reproduction and aging. Frontiers in Endocrinology publishes rigorously peer-reviewed research from basic molecular and cellular communication to clinical care, advancing our understanding of the endocrine system, and leading to novel therapies for some of the most prevalent health issues such as obesity, diabetes, reproduction and aging.. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Different studies have estimated prevalence of unilateral disease between 4.5 and 14% (13, 25, 29–31), while asymmetry was evident in 9–34% of patients with GO (13, 26, 32). doi: 10.1007/s10792-020-01571-6, 34. Moreover, disease severity is assessed similarly to bilateral disease, using clinically evaluated standardized tools, such as CAS (27) and Vision, Inflammation, Strabismus, Appearance (VISA) (28). Laurberg P, Wallin G, Tallstedt L, Abraham-Nordling M, Lundell G, Torring O. TSH-receptor autoimmunity in Graves’ disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. J Plastic Reconstr Aesthet Surg (2007) 60:246–50. Frontiers in Endocrinology Journal Impact (Facteur d'impact) 2019: 3.630 (Dernières données en 2020). Cloudflare Ray ID: 6044941f696532aa N Engl J Med (2010) 362:726–38. 11:589994. doi: 10.3389/fendo.2020.589994. International Scientific Journal & Country Ranking. Indian J Ophthalmol (2011) 59:363–6. Quality of life in a german graves orbitopathy population. doi: 10.1046/j.1365-2265.1997.2331047.x, 28. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Graves’ Orbitopathy (GO) is an autoimmune orbital disorder usually presenting as a sequala of autoimmune thyroid disease. , Iran 354 Chinese cases found no significant correlation with asymmetric disease cessation and... 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