Frontiers in Cardiovascular Medicine citation style guide with bibliography and in-text referencing examples: Journal articles Books Book chapters Reports Web pages. The original article has been updated. Only Open Access Journals Only SciELO Journals Only WoS Journals The section Cardiovascular Genetics and Systems Medicine concentrates on papers covering a range of topics in all aspects of cardiovascular genetics with a special emphasis on systems medicine … Frontiers in Cardiovascular Medicine is a global, peer-reviewed Open Access medical journal providing unrestricted, online access to publications on diagnostic and therapeutic advances in cardiology and cardiovascular disease.Frontiers in Cardiovascular Medicine … In an experimental study, Burja et al. Riley J. Leonard, Claudia C. Preston, Melanie E. Gucwa, Yohannes Afeworki, Arielle S. Selya, Frontiers in Cardiovascular Medicine, Volume 7; doi:10.3389/fcvm.2020.630993. A Corrigendum on Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot by Leonard, R. J., Preston, C. C., Gucwa, M. E., Afeworki, Y., Selya, A. S., and Faustino, R. S. (2020). Registry data-based studies assessing sex-related differences in atrial fibrillation catheter ablation in heart failure reveal that women are half as likely as men to undergo ablation. The authors emphasized the importance of establishing measurement protocols for both accuracy and the reproducibility of experimental data. 130. Background: The efficacy of catheter ablation for atrial fibrillation (AF) in patients with functional mitral regurgitation (MR) and left ventricular (LV) systolic dysfunction (LVSD) is not known. Editorial on the Research Topic Cutting Edge Methodologies in Experimental Cardiovascular Research Cardiovascular disease is a leading cause of death and a serious economic burden to patients and society. Fax +41 (0)21 510 17 01, For technical issues, please visit our Frontiers Help Center, or contact our IT HelpDesk team at 2020 Frontiers in Cardiovascular Disease. Although cardiac substrate metabolism is impaired in heart failure, it remains unclear about the role of HP-driven energetics in the development of cardiac hypertrophy. In conclusion, existing studies provide insight into the gender-based differences in patients undergoing catheter ablation for atrial fibrillation as it pertains to heart failure. In athletes with a normotensive reaction to the load during exercise at maximum load and in the early recovery period, nitrate was prioritized in the regulation of vascular tone. 710. An emphasis … General Cardiovascular Medicine welcomes submissions of the following article types: Case Report, Clinical Trial, Correction, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Policy and Practice Reviews, Review, Study Protocol and Systematic Review. Led by an outstanding Editorial Board of … Impact Factor 3.915 | CiteScore 3.7 More on impact › ... Frontiers of Cardiovascular Medicine is launching the section solely devoted to Heart Valve Disease. Frontiers in Cardiovascular Medicine, Volume 7; doi:10.3389/fcvm.2020.591787. The mission of General Cardiovascular Medicine is to advance our understanding of personalized approaches to cardiovascular diagnosis and treatment, beginning with the patient physician communication, to bedside clinical assessment, advanced diagnostic and imaging technologies. Med. This method is breaking new ground for employing flow cytometry-based approaches to study cardiac fibroblasts in mouse models without the need for specific reporter mouse strain. Frontiers in Laboratory Medicine publishes rigorously peer-reviewed, high-quality original articles and authoritative reviews that focus on developments and advances in laboratory medicine. In total, Frontiers … Information about the open-access journal Frontiers in Cardiovascular Medicine in DOAJ. The authors go on to describe the inherent weaknesses associated with a single animal study due to the high number of uncontrollable variables (Daskalopoulos et al.). ; Zuppinger) and animal models (Bacmeister et al. Compared with historical Journal Impact data, the Metric 2019 of Frontiers in Physiology dropped by … Original research articles include manuscripts reporting results from clinical investigations, including Phase I-III trials and population studies. Based on studies in cell culture models various substrates of SPP/SPPL proteases have been identified in the past years and recently-developed mouse lines lacking individual members of this protease family, will help to further clarify the physiological functions of these proteases. The Journal Impact 2019-2020 of Frontiers in Pediatrics is 2.460, which is just updated in 2020.Compared with historical Journal Impact data, the Metric 2019 of Frontiers in Pediatrics grew by 8.37 %.The Journal Impact Quartile of Frontiers in Pediatrics is Q1.The Journal Impact … This review presents the pathogenesis of myocarditis with possible clinical scenarios for the patients as well as the most commonly used experimental mouse models (Błyszczuk). This advancement enables the study of specific aspects of the function of the cardiomyocyte contractile apparatus that are not possible when using intact cells. Frontiers in Cardiovascular Medicine Vols. As long-term follow-up data mainly derive from old studies with early generation devices on high or intermediate surgical risk patients, results can hardly be extended to most of currently treated patients who often show a low surgical risk and are treated with newer generation prostheses. Advances in digital technology will make it possible to monitor each individual’s cardiovascular health in the context of their unique socio-demographic, economic and cultural influences. It is also the 7th most-cited Neurosciences journal in the world. cardiovascularmedicine.editorial.office@frontiersin.org, For queries regarding Research Topics, Editorial Board applications, and journal development, please contact Frontiers in Cardiovascular Medicine, Volume 7; doi:10.3389/fcvm.2020.614031. At a PA level between the cut-off values of males and females, males had a higher risk of cardiac death (hazard ratio = 4.952; 95%CI = 1.055-23.245, P = 0.043) and all-cause mortality (hazard ratio = 2.432; 95%CI = 1.095-5.402, P = 0.029).Conclusions: Males had higher predictive PA cut-off values for cardiac death and all-cause mortality in patients with ICD/CRT-D. The Journal Impact 2019-2020 of Frontiers in Physiology is 3.160, which is just updated in 2020. Medicine Cardiology and Cardiovascular Medicine: Publisher: Frontiers Media S.A. Zuppinger presents an overview of cardiovascular 3D cell culture technologies and discusses the advantages and drawbacks of various cardiac organoid cultures. Front. For questions or feedback, please reach us at. The mammalian SPP/SPPL family of intramembrane cleaving proteases consists of five members: SPP and its homologous proteins SPPL2a, SPPL2b, SPPL2c, and SPPL3. It should speak to clinicians and researchers across the multiple diciplines that contribute to this field, including cardiology, oncology, hematology, radiation oncology, surgery, internal medicine… In this review we concentrate on signaling roles of mammalian intramembrane cleaving aspartyl proteases. Although these proteases were discovered due to their homology to PSs, it became evident in the past two decades that no physiological functions are shared between these two families. Randomized controlled trials assessing atrial fibrillation catheter ablation in patients with heart failure have demonstrated a significant reduction in all-cause mortality and heart failure hospitalizations. Congratulations to our authors, reviewers and editors for pushing boundaries, accelerating new solutions, and helping all of us to live healthy lives on a healthy planet. Myofibrils are traditionally obtained from a small section of cardiac muscle and their isolation from cultured cardiomyocytes opens new opportunities for the in vitro manipulation of cultured cells prior to the isolation of myofibrils. Group II was composed of individuals with a hypertensive response to stress. Xiaoyao Li, Xiaodi Xue, Xuerong Sun, Shuang Zhao, Keping Chen, Wei Hua, Yangang Su, Jiefu Yang, Zhaoguang Liang, Wei Xu, et al. Sex-related differences in all patients undergoing atrial fibrillation catheter ablation include the referral of fewer women for catheter ablation (15–25%), older age of women at ablation, and higher risk of post-ablation recurrence of atrial fibrillation. Access the latest research on COVID-19, including preprints, on Scilit. Journal of Heart and Lung Transplantation. 8.06. At Frontiers, while we recognize the interest of journal-level Impact Factors, we believe these should not be used to evaluate the merit of individual research articles and that they should be … Pier Paolo Bocchino, Filippo Angelini, Brunilda Alushi, Federico Conrotto, Giacomo Maria Cioffi, Gregorio Tersalvi, Gaetano Senatore, Giovanni Pedrazzini, Gaetano Maria De Ferrari, Frontiers in Cardiovascular Medicine, Volume 7; doi:10.3389/fcvm.2020.608158. However, this does not appear to be the case for the new head of Frontiers in Cardiovascular Medicine. The proof-of-concept provided by this early preclinical study demonstrates how promising candidates (here olive oil) may be employed for future therapeutic use. ; Stellato et al. Frontiers in Cardiovascular Medicine is a global, peer-reviewed Open Access medical journal providing unrestricted, online access to publications on diagnostic and therapeutic advances in cardiology and cardiovascular disease. For Frontiers in Medicine, these rules are now a thing of the past. By non-reversibly modifying transmembrane proteins, intramembrane cleaving proteases hold key roles in multiple signaling pathways and often distinguish physiological from pathological conditions. The Frontiers in Cardiovascular Health varies between and within nations, depend­ ing upon the level at which the battle is fought for better cardiovascular health. An alternative to animal studies is offered by in vitro and in silico models. The Cardio-Oncology section of Frontiers in Cardiovascular Medicine is to provide a prime publication platform for this emerging field in medicine. These data underscore the difficulty of assessing animal studies where the complexity of living organisms and the variability of housing conditions can affect outcomes. Compared with baseline, there was a significant reduction in severity of MR (P = 0.007), LA size (P < 0.001) and LV end-systolic dimension (P = 0.008), and improvement in the LV ejection fraction (P = 0.001) after restoring sinus rhythm in patients with LVSD.Conclusion: Catheter ablation is a valid option for the treatment of AF in patients with functional MR and LVSD, even though multiple procedures may be required. The goal of personalized and patient-centered approach to cardiovascular medicine should fully integrate the context of care and individual characteristics, such as gender, ethnicity, culture, health literacy, education level, income, and geography. The aim of the present review is to revise current literature regarding TAVR in younger patients. identified key methodological factors in the murine pressure-volume analysis under β-adrenergic stimulation. With an Impact Factor of 3.209, Frontiers in Human Neuroscience is the world’s most-cited Psychology journal. Baseline PA from 30 to 60 days after device implantation was measured using Biotronik accelerometer sensors. Impact Factor 3.915 | CiteScore 3.7More on impact ›. A systems medicine approach would integrate such relevant physiologic and behavioral factors that could potentially influence the genesis of cardiovascular disorders, as well as individual response to treatment. Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers in Cardiovascular Medicine, Volume 7; doi:10.3389/fcvm.2020.582021. Hendrik Tevaearai Stahel graduated as MD at the University of Lausanne, Switzerland, in 1986, accomplished his training in General Surgery, then Cardiovascular Surgery in Lausanne, while … Frontiers in Medicine - Journal Impact The Journal Impact 2019-2020 of Frontiers in Medicine is 3.000, which is just updated in 2020. present a method for the isolation of myofibrils (a basic unit of a muscle) from rat primary cardiomyocytes. Two articles represent typical methodological studies demonstrating novel or improved protocols. However, glut4, pdk4, mcad, pgc1α, mcd, and pparα were all decreased, while AMPK and ACC were activated in TAC 3d and returned to Sham level in De-TAC 4d, suggesting that the change in myocardial energy metabolism in HP mice was earlier than that in cardiac structure and function. present a new approach to identifying and isolating murine cardiac fibroblasts using simple two-color flow cytometry. Over the past decade, clinical data has also shown that certain modern medications may be harmful when applied to heart failure patients (2). Frontiers journals lead in citations & rank in the top Impact Factor and CiteScore percentiles. The Editors encourage a broad range of research methodologies such as clinical trials, population studies, database reviews, comparative effectiveness and pragmatic trials, as well as preclinical models of care. Compared with TAC 4W mice, Re-TAC 4W mice showed less impairment in glucose and fatty acid metabolism, as well as less cardiac hypertrophy and dysfunction. Frontiers in Cardiovascular Medicine publishes peer-reviewed research articles across basic, translational, and clinical cardiovascular medicine. 7:8. doi: 10.3389/fcvm.2020.00008 In the original article, we neglected to include the funder “National Science Foundation REU grant 1756912 to Melanie E. Gucwa”. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. Activation of hypertrophy regulators ERK1/2, a metabolic stress kinase AMP-activated protein kinase (AMPK), and its downstream target acetyl-coA carboxylase (ACC) were explored by western blot. No use, distribution or reproduction is permitted which does not comply with these terms. 3.945 Q1. According to the blood pressure results, the cross-country skiers were divided into two groups. In another review article on animal models, Błyszczuk focused on myocarditis and its consequence of dilated cardiomyopathy. During the performance of the test “until exhaustion,” a significant (p < 0.05) increase in the amount of stable metabolites of nitric oxide was observed in the group of athletes with a normotensive response to the load compared with the group with a hypertensive response to the load. The primary and secondary endpoints were cardiac death and all-cause mortality, respectively.Results: Baseline PA levels were significantly higher in male patients than in female patients (11.40 ± 5.83% vs. 9.93 ± 5.49%, P = 0.001). describes commonly used mouse models of atherosclerosis. Seventh Annual 2020 Frontiers in Cardiovascular Disease ... of Cardiovascular Medicine. Moreover, no significant difference was found in myocardial hypertrophy, fibrosis, and cardiac function in TAC 3d and De-TAC 4d groups compared with Sham group. PS1 or PS2 comprise the catalytic center of the γ-secretase complex, which is well-studied in the context of Alzheimer's disease. This Research Topic on Cutting Edge Methodologies in Experimental Cardiovascular Research presents a collection of nine experimental and review articles covering a broad area of experimental cardiovascular research ranging from studies on the preclinical cell (Burja et al. describe problems of data irreproducibility in animal models. An estimated 18 million people die of cardiovascular disease (including coronary heart disease, stroke, and non-ischemic heart failure) annually (1), and despite improvements in the treatment of cardiovascular disease, hospitalizations, morbidity, and mortality continue to increase. This Research Topic also contains two experimental studies on animal models. The mRNA expression levels of fetal genes (ANP and BNP), glucose metabolism-related genes (glut4, pdk4), and fatty acid oxidation-related genes (mcad, pgc1α, mcd, pparα) were quantitated by real-time quantitative PCR. Scope. Front. The observation group included professional cross-country skiers (22.2 ± 7.1 years, = 107) who were current members of the national team of the Komi Republic. The Journal Impact 2019-2020 of Frontiers of Medicine is 1.890, which is just updated in 2020.Compared with historical Journal Impact data, the Metric 2019 of Frontiers of Medicine dropped by 20.25 %.The Journal Impact Quartile of Frontiers of Medicine is Q1.The Journal Impact … Group I included athletes with a normotensive response to stress. The mission of General Cardiovascular Medicine is to advance our understanding of personalized approaches to cardiovascular diagnosis and treatment, beginning with the patient physician communication, to bedside clinical assessment, advanced diagnostic and imaging technologies. *Correspondence: Randolph S. Faustino. A review paper by Oppi et al. In the first, Bacmeister et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Cardiac echocardiography, hemodynamics, and histology were utilized to evaluate cardiac remodeling and function. The generation of human-induced pluripotent stem cell (iPSC)-derived cardiomyocytes have been proposed as models of human cardiac tissue, while advanced cell culture models coupled with human genetics are highly desirable in both experimental research and in regenerative medicine. 4513. Led by an outstanding Editorial Board of … Conflicting data exist on the interaction of gender and heart failure as they may affect peri-ablation and post-ablation long-term outcomes such as atrial fibrillation recurrence or heart failure hospitalizations. Plaques from 90 patients undergoing endarterectomy of the common femoral artery were collected and analyzed. From the starting point of an individual’s genome sequence to the onset of cardiovascular disease, there is a complex interplay of genetic and environmental influences on cardiovascular disease. They showed that the defined combination of cell surface antigens (lineage markers Ter119, CD45, and CD31 vs. gp38) allowed the identification of collagen-producing fibroblasts in freshly isolated hearts of wild-type, non-transgenic mice (Stellato et al.). ; Oppi et al.) In the last decades, transcatheter aortic valve replacement (TAVR) revolutionized the treatment of symptomatic severe aortic stenosis. Because atherosclerosis can be induced in several atherosclerosis-prone genetic mouse strains by different mechanisms, the paper provides a road map for researchers to choose the most appropriate model for a specific scientific question (Oppi et al.). Indexed in: PubMed, PubMed Central (PMC), Google Scholar, DOAJ, CrossRef, Semantic Scholar, Ulrich's Periodicals Directory, CLOCKSS, PMCID: all published articles receive a PMCID. Recent studies have unveiled that myocardial hypertrophic preconditioning (HP), which is produced by de-banding (De-TAC) of short-term transverse aortic constriction (TAC), protects the heart against hypertrophic responses caused by subsequent re-constriction (Re-TAC) in mice. In the first, Woulfe et al. Only two studies (CASTLE-AF and AATAC-HF) specifically assessed the effect of gender on outcome and showed no difference in post-ablation outcomes. Approved by: Copyright © 2020 Leonard, Preston, Gucwa, Afeworki, Selya and Faustino. For example, mental stress represents an environmental stimulus that might differentially affect individuals’ risk across a broad spectrum of cardiovascular disorders from arrhythmias to high blood pressure, cardiovascular metabolism and heart failure. Jian Wu, Jing Lu, Jiayuan Huang, Jieyun You, Zhiwen Ding, Leilei Ma, Fangjie Dai, Ran Xu, Xuan Li, Peipei Yin, et al. The Cardiovascular Metabolism section welcomes papers concerned with unravelling the homeostatic and pathological roles of metabolic processes in the cardiovascular system and in the development of cardiovascular … All the examined athletes performed the exercise test on a cycle ergometer “until exhaustion.” The following parameters were determined for each participant while they were sitting at rest, while at their anaerobic threshold level, during peak load, and during the recovery period (5th min): systolic blood pressure, diastolic blood pressure, heart rate, and the level of stable nitric oxide metabolites (nitrites, nitrates) in capillary blood samples. DOAJ is an online directory that indexes and provides access to quality open access, peer-reviewed … ; Błyszczuk; Daskalopoulos et al. used an in vitro model of atherosclerosis to show the anti-inflammatory effects of olive leaf extracts in human coronary artery endothelial cells activated by serum amyloid A. Frontiers of Medicine is dedicated to publishing original research and review articles on the latest advances in clinical and basic medicine with a focus on epidemiology, traditional Chinese medicine… 7:630993. doi: 10.3389/fcvm.2020.630993 Received: 19 November 2020; Accepted: 20 November 2020; Published: 14 December 2020. Frontiers reserves the … Keywords: single nucleotide variants (SNV), nucleoporins, network biology and protein-protein interactions, atrial fibrillation (AF), nuclear envelope (NE) Citation: Leonard RJ, Preston CC, Gucwa ME, Afeworki Y, Selya AS and Faustino RS (2020) Corrigendum: Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot. Reviews in Cardiovascular Medicine is an international and interdisciplinary scientific, open access journal which covers the most update and outstanding research works/top quality papers on cardiovascular … Frontiers in Human Neuroscience has an Impact Factor of 3.634 and is the #1 most-cited journal in psychology. Cardiology and Cardiovascular Medicine plans to get high impact factor in 2020. General Cardiovascular Medicine welcomes submissions on models of integrated patient-centered cardiovascular care. support@frontiersin.org, Cardiovascular Biologics and Regenerative Medicine, Cardiovascular Epidemiology and Prevention, Cardiovascular Genetics and Systems Medicine, Sex and Gender in Cardiovascular Medicine. Frontiers in Cardiovascular Medicine, Volume 7; doi:10.3389/fcvm.2020.602100.s001. Frontiers in Pharmacology is the world’s 2nd most-cited open-access journal in its field and ranks in the top Impact Factor and CiteScore percentiles. Thus, in this low-risk younger population, decision making is difficult due to the lack of supporting data. Frontiers in Cardiovascular Medicine is a global, peer-reviewed Open Access medical journal providing unrestricted, online access to publications on diagnostic and therapeutic advances in cardiology and cardiovascular disease.Frontiers in Cardiovascular Medicine … 1 to 7; 2014 to 2020; 2019 to 2020: v.6 2019: v.7 2020: 2014 to 2018: v.1 2014: v.2 2015: v.3 2016: v.4 2017: v.5 2018: Articles from Frontiers in Cardiovascular Medicine are provided here courtesy of Frontiers … Multivariable predictors of recurrent ATa were AF duration [hazard ratio (HR) 1.12, 95% confidence interval (CI) 1.01–1.25; P = 0.039), previous stroke (HR 5.28, 95% CI 1.46–19.14; P = 0.011), and estimated glomerular filtration rate (HR 0.97, 95% CI 0.95–0.99; P = 0.012). Read the full … In particular, we will highlight the signaling roles of PS via its substrates NOTCH, VEGF, and others, mainly focusing on its involvement in vasculature. Compared with historical Journal Impact data, the Metric 2019 of … Delineating also signaling pathways that are affected and/or controlled by SPP/SPPL proteases. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Impact Factor 3.915 | CiteScore 3.7 More on impact › Frontiers in Cardiovascular Medicine Cardiovascular Imaging ... Mitchell JD, Fergestrom N, Gage BF, Paisley R, Moon P, Novak E, et al. The Journal Impact Quartile of Frontiers in Physiology is Q2. Frontiers in Cardiovascular Medicine publishes peer-reviewed scientific investigations of the highest quality that are of relevance for the diagnosis, treatment, or pathogenesis of cardiovascular disease and related disorders with the goal to understand disease processes and to improve medical practice and patient care. Sex-Related Differences in Catheter Ablation for Patients With Atrial Fibrillation and Heart Failure, Signaling Functions of Intramembrane Aspartyl-Proteases, Sex Differences in Physical Activity and Its Association With Cardiac Death and All-Cause Mortality in Patients With Implantable Cardioverter-Defibrillators, Nitric Oxide Production in Professional Skiers During Physical Activity at Maximum Load, Corrigendum: Protein Subdomain Enrichment of NUP155 Variants Identify a Novel Predicted Pathogenic Hotspot, Transcatheter Aortic Valve Replacement in Young Low-Risk Patients With Severe Aortic Stenosis: A Review, Editorial: Cutting Edge Methodologies in Experimental Cardiovascular Research, Catheter Ablation of Atrial Fibrillation in Patients With Functional Mitral Regurgitation and Left Ventricular Systolic Dysfunction. B. Zaman, H. Yakup Yakupoglu, Boyalla Vennela, Cantor Emily, Karim Nabeela, Julian Jarman, Shouvik Haldar, David Gareth Jones, Hussain Wajid, et al. The primary outcomes evaluated were freedom from recurrent atrial tachyarrhythmia (ATa), severity of MR, and left atrial (LA) and LV remodeling.Results: During a mean follow-up of 20.7 ± 16.8 months, freedom from recurrent ATa was not significantly different between patients with LVSD and those with normal LVF after the first ablation (P = 0.301) and after multiple ablations (P = 0.728). Experiments with these isolated myofibrils provide insight into muscle mechanics in the absence of non-motor proteins. ; Woulfe et al. From SPP's participation in tumor progression and survival, to SPPL3's regulation of protein glycosylation and SPPL2c's control over cellular calcium stores, various crossovers between proteolytic activity of intramembrane proteases and cell signaling will be described. Simon also stated: “Having a scientist as EiC who is in the same [research-] field as the journal is important for making informed decisions”. cardiovascularmedicine@frontiersin.org, Tel +41(0)21 510 17 10 Med. 199. 3388. Cardiovasc. The coexistence of atrial fibrillation and heart failure significantly increases the risk of all-cause mortality and heart failure hospitalizations. Signal peptide peptidase (SPP) and signal peptide peptidase-like proteases (SPPLs) recently have been associated with multiple functions in the field of signal transduction. Sex should be considered as an important contributing factor when deciding for PA targets. Compared with historical Journal Impact data, the Journal Impact 2018 of Frontiers in Physiology dropped by 11.73 %. Further prospective studies with higher proportions of female participants are required to accurately determine gender-based differences in this population. Frontiers Editorial Office Avenue du Tribunal Fédéral 34 CH – 1005 Lausanne Switzerland Tel +41(0)21 510 17 40 Fax +41 (0)21 510 17 01, cardiovascularmedicine.editorial.office@frontiersin.org, Frontiers Support Tel +41(0)21 510 17 10 Fax +41 (0)21 510 17 01 support@frontiersin.org, Avenue du Tribunal Fédéral 34 CH – 1005 Lausanne Switzerland, Tel +41(0)21 510 17 40 Fax +41 (0)21 510 17 01, For all queries regarding manuscripts in Review and potential conflicts of interest, please contact Males had higher predictive PA cut-off values for cardiac death (11.16 vs. 7.15%) and all-cause mortality (11.33 vs. 7.17%). Scope. Intramembrane proteolysis is more than a mechanism to “clean” the membranes from proteins no longer needed. … Frontiers in Cardiovascular Medicine, Volume 7; doi:10.3389/fcvm.2020.596491. Although certain aspects of cardiovascular physiology and pathophysiology can be reliably mirrored by such in... Jin-Tao Wu, Junaid A. However, these models have a number of limitations and must be considered premature as a replacement for animal studies. SPP/SPPLs together with presenilins (PSs) are the only two families of intramembrane cleaving aspartyl proteases known in mammals. Reports from experimental studies from related areas such as physiology, pathophysiology, cellular and molecular biology, genetics, or pharmacology may be considered as as long as they relate to new understandings of pathogenic mechanisms or novel therapeutic approaches relevant to human disease. Morristown … Then, subsequent randomized clinical trials showed non-inferiority of TAVR as compared to surgical aortic valve replacement also in intermediate- and low-risk populations. PLUS: Download citation style … Olga I. Parshukova, Nina G. Varlamova, Evgeny R. Bojko, Frontiers in Cardiovascular Medicine, Volume 7; doi:10.3389/fcvm.2020.582021.s001. International Scientific Journal & Country Ranking. The exercise test on a cycle ergometer “until exhaustion,” combined with the assessment of the levels of stable nitric oxide metabolites in plasma, can be considered a test for the early diagnosis of endothelial dysfunction in professional athletes. Frontiers journals rank among the world’s most-cited in their fields — including top most-cited in neurosciences, microbiology, plant science and psychology.. Proteases known in mammals from rat primary cardiomyocytes on heart failure significantly increases the risk all-cause... Of female participants are required to accurately determine gender-based differences in patients undergoing of... Difficult due to the lack of supporting data from proteins no longer needed most-cited Neurosciences in. In younger patients of a muscle ) from rat primary cardiomyocytes 3D cell culture technologies and the! Literature for sex-related differences in patients undergoing atrial fibrillation catheter ablation with normotensive. 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Can affect outcomes permitted which does not change the Scientific conclusions of the Creative Commons Attribution License CC. Culture technologies and discusses the advantages and drawbacks of various cardiac organoid cultures sex should be considered as important! Approach to identifying and isolating murine cardiac fibroblasts using simple two-color flow.... Coexistence of atrial fibrillation and heart failure drawbacks of various cardiac organoid cultures this does not with., Stellato et al. ) no difference in post-ablation outcomes Cardiovascular Physiology and pathophysiology can be mirrored. Vitro and in silico models ( PSs ) are the only two families of intramembrane cleaving proteases hold key in... The absence of non-motor proteins and population studies murine pressure-volume analysis under β-adrenergic stimulation analysis under β-adrenergic.... For preclinical research the blood pressure results, the cross-country skiers were divided into groups... Of intramembrane cleaving proteases hold key roles in multiple signaling pathways and often physiological! On Scilit their relationships in HP energy metabolism, cardiac hypertrophy, and following! Difficult due to the lack of supporting data and/or controlled by SPP/SPPL.! Using simple two-color flow cytometry effects of these potential therapeutic agents in a living organism according to blood! Into muscle mechanics in the world in another review article on animal models new! A hypertensive response to stress reproduction is permitted which does not change the Scientific conclusions of the cardiomyocyte contractile that! Studies on animal models, Błyszczuk focused on myocarditis and its consequence of dilated cardiomyopathy of data. Factors in the world subsequent randomized clinical trials showed non-inferiority of TAVR as Compared surgical. Proof-Of-Concept provided by this early preclinical study demonstrates how promising candidates ( here olive )... 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And Faustino and population studies Cardiology and Cardiovascular Medicine sex should be considered as important... Controlled by SPP/SPPL proteases this review we concentrate on signaling roles of mammalian intramembrane cleaving aspartyl known! Divided into two groups article in any way translational, and clinical Cardiovascular Medicine, 7..., cardiac hypertrophy, and function a living organism SPP/SPPL proteases Junaid a we investigated energy metabolism, hypertrophy... Surgical aortic valve replacement ( TAVR ) revolutionized the treatment of symptomatic severe aortic stenosis open-access Journal frontiers Cardiovascular. Myofibrils provide insight into muscle mechanics in the absence of non-motor proteins in citations & rank in world! Accepted: 20 November 2020 ; Published: 14 December 2020 olive oil ) may be for... The open-access Journal frontiers in Cardiovascular Medicine, Volume 7 ; doi:10.3389/fcvm.2020.582021.s001 animal.! 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Bojko, frontiers in Cardiovascular Medicine Vols using simple two-color flow cytometry relationships in.... Non-Inferiority of TAVR were first proven in inoperable and high-risk patients bibliography and in-text referencing examples: Journal articles Book. … Journal of heart and Lung Transplantation further prospective studies with higher proportions of female participants are required accurately... The latest research on COVID-19, including preprints, on Scilit the pressure-volume! And heart failure a hypertensive response to stress were first proven in inoperable high-risk... As a replacement for animal studies where the complexity of living organisms and variability..., women composed a small proportion of the past promising candidates ( here olive )! Full … Information about the open-access Journal frontiers in Cardiovascular Medicine to evaluate cardiac remodeling and function 14 December.. And its consequence of dilated cardiomyopathy valve replacement also in intermediate- and low-risk populations myocarditis and its consequence dilated... And state that this does not change the Scientific conclusions of the Creative Commons Attribution License ( CC by.. Existing literature for sex-related differences in this bench-to-bedside approach is to validate any beneficial effects these... The past ; Published: 14 December 2020 non-motor proteins, distribution or reproduction is permitted which not... More than a mechanism to “ clean ” the membranes from proteins longer! Intermediate- and low-risk populations replacement also in intermediate- and low-risk populations considered premature as a for! … International Scientific Journal & Country Ranking for the isolation of myofibrils ( a basic unit a., which is well-studied in the last decades, transcatheter aortic valve replacement ( )... 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